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Description reviews

Indications of Glifo 10 mg

Glifo 10 mg is indicated in: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. To reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and established cardiovascular disease.

Theropeutic Class

Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Pharmacology

Glifo 10 mg is a sodium glucose co-transporter-2 (SGLT-2) inhibitor. SGLT2 co-transporters are responsible for reabsorption of glucose from the glomerular filtrate in the kidney. The glucuretic effect resulting from SGLT2 inhibition reduces renal absorption and lowers the renal threshold for glucose, resulting in increased glucose excretion. Additionally, it contributes to reduced hyperglycaemia, assists weight loss, and reduces blood pressure.

Dosage & Administration of Glifo 10 mg

The recommended dose of Glifo 10 mg is 10 mg once daily, taken in the morning, with or without food. In patients tolerating Glifo 10 mg, the dose may be increased to 25 mg once daily. In patients with volume depletion, correcting this condition prior to initiation of Glifo 10 mg is recommended.

Dosage of Glifo 10 mg

Interaction of Glifo 10 mg

Diuretics: Co-administration of Glifo 10 mg with diuretics resulted in increased urine volume. Insulin or Insulin Secretagogues: Co-administration of Glifo 10 mg with insulin or insulin secretagogues increases the risk for hypoglycemia. Positive Urine Glucose Test: Monitoring glycemic control with urine glucose tests is not recommended in patients taking SGLT2 inhibitors as SGLT2 inhibitors increase urinary glucose excretion and will lead to positive urine glucose tests. Use alternative methods to monitor glycemic control. Interference with 1,5-anhydroglucitol (1,5-AG) Assay: Monitoring glycemic control with 1,5-AG assay is not recommended as measurements of 1,5-AG are unreliable in assessing glycemic control in patients taking SGLT2 inhibitors. Use alternative methods to monitor glycemic control.

Contraindications

Glifo 10 mg is contraindicated in patients with history of serious hypersensitivity reaction to Glifo 10 mg or any of its ingredients, severe renal impairment, end-stage renal disease, or dialysis.

Side Effects of Glifo 10 mg

The most common adverse reactions associated with Glifo 10 mg are urinary tract infections and female genital mycotic infections. Others common side effects includes dehydration, hypotension, weakness, dizziness and increased thirstiness.

Pregnancy & Lactation

There are no adequate and well-controlled studies of Glifo 10 mg in pregnant women. Glifo 10 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if Glifo 10 mg is excreted in human milk. It is not recommended when breastfeeding.

Precautions & Warnings

Assessment of renal function is recommended prior to initiation of Glifo 10 mg and periodically thereafter. Glifo 10 mg should not initiated in patients with an eGFR less than 45 ml/min/1.73 m2. No dose adjustment is needed in patients with an eGFR greater than or equal to 45 ml/min/1.73 m2.

Overdose Effects of Glifo 10 mg

In the event of an overdose with Glifo 10 mg the usual supportive measures (e.g., remove unabsorbed material from the gastrointestinal tract, perform clinical monitoring, and institute supportive treatment) should be employed. Removal of Glifo 10 mg by hemodialysis has not been studied.