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Description reviews

Indications of Lacicard 4 mg

Lacicard 4 mg is indicated for the treatment of hypertension either alone or in combination with other antihypertensive agents, including ß-blockers, diuretics, ACE-inhibitors etc.

Theropeutic Class

Calcium-channel blockers

Pharmacology

Lacicard 4 mg inhibits the influx of calcium into smooth muscle cells by the competitive inhibition of voltage-dependent calcium 'L' channels. This action results in the inhibition of the effects triggered by the influx of calcium into the cells, such as the activation of the contractile proteins in smooth muscle.

Dosage & Administration of Lacicard 4 mg

The recommended initial dose of Lacicard 4 mg is 2 mg once daily. The dose may be increased to 4 mg and then, if necessary, to 6 mg after 3 to 4 weeks. Lacicard 4 mg should be taken preferably in the morning.

Dosage of Lacicard 4 mg

Interaction of Lacicard 4 mg

The plasma concentration of Lacicard 4 mg may be increased by simultaneous administration of cimetidine. No specific pharmacodynamic interaction problems have been identified in studies with common antihypertensive agents or with digoxin, tolbutamide or warfarin.

Contraindications

Hypersensitivity to any ingredient of this product, cardiogenic shock, unstable angina, aortic stenosis, avoid within 1 month of myocardial infarction, impaired left ventricular function.

Side Effects of Lacicard 4 mg

Lacicard 4 mg is generally well tolerated. Some individuals may experience minor side effects like flushing, palpitation, edema, headache, dizziness, rarely gastro-intestinal disturbances, gum hyperplasia, mood disturbances, asthenia, polyuria, muscle cramps, skin rash etc.

Pregnancy & Lactation

Pregnancy: There are no data on the safety of Lacicard 4 mg in human pregnancy. Lacicard 4 mg provides no evidence of a teratogenic effect in animal study.Lactation: Milk transfer studies in animals have shown that Lacicard 4 mg (or its metabolites) are likely to be excreted into breast milk. There is, however, no clinical experience of Lacicard 4 mg in pregnancy and lactation. Accordingly, Lacicard 4 mg should not be used during pregnancy or lactation.

Precautions & Warnings

Cardiac conduction abnormalities, poor cardiac reserves, hepatic impairment, withdraw if ischemic pain occurs shortly after initiating treatment or if cardiogenic shock develops, avoid grape fruit juice.

Overdose Effects of Lacicard 4 mg

Symptoms: Prolonged peripheral vasodilation associated with hypotension and tachycardia, bradycardia or prolonged AV conduction.Management: Symptomatic and supportive treatment.

Storage Conditions

Store in a cool and dry place, protect from light and moisture. Keep out of the reach of children.

Use In Special Populations

Use in Neonates: There are no data on safety or efficacy of Lacicard 4 mg in neonates.Use in children: Treatment with Lacicard 4 mg have not been evaluated in Children.Hepatic Impairment: Severe: Reduce dose.